PDBe 3dcy

X-ray diffraction
1.75Å resolution

Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens.

Released:
Source organism: Homo sapiens
Entry authors: McCoy JG, Bingman CA, Wesenberg GE, Phillips Jr GN, Center for Eukaryotic Structural Genomics (CESG)

Function and Biology Details

Reaction catalysed:
Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fructose-2,6-bisphosphatase TIGAR Chain: A
Molecule details ›
Chain: A
Length: 275 amino acids
Theoretical weight: 31.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: NEW Q9NQ88 (Residues: 2-270; Coverage: 100%)
Gene names: C12orf5, TIGAR
Sequence domains: Histidine phosphatase superfamily (branch 1)
Structure domains: Phosphoglycerate mutase-like

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P212121
Unit cell:
a: 40.983Å b: 76.408Å c: 79.536Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.18 0.229
Expression system: Escherichia coli