PDBe 3dac

X-ray diffraction
1.8Å resolution

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein Mdm4 Chains: A, M
Molecule details ›
Chains: A, M
Length: 130 amino acids
Theoretical weight: 14.77 KDa
Source organism: Danio rerio
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7ZUW7 (Residues: 15-129; Coverage: 23%)
Gene names: mdm4, mdmx
Sequence domains: SWIB/MDM2 domain
Structure domains: SWIB/MDM2 domain
Cellular tumor antigen p53 Chains: B, P
Molecule details ›
Chains: B, P
Length: 21 amino acids
Theoretical weight: 2.4 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04637 (Residues: 17-37; Coverage: 5%)
Gene names: P53, TP53

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 66.43Å b: 30.81Å c: 70.09Å
α: 90° β: 107.43° γ: 90°
R-values:
R R work R free
0.207 0.205 0.243
Expression systems:
  • Escherichia coli
  • Not provided