PDBe 3d91

X-ray diffraction
2.2Å resolution

Human renin in complex with remikiren

Released:
Source organism: Homo sapiens
Entry authors: Prade L, Bezencon O, Bur D, Weller T, Fischli W, Remen L

Function and Biology Details

Reaction catalysed:
Cleavage of Leu-|- bond in angiotensinogen to generate angiotensin I.
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Renin Chains: A, B
Molecule details ›
Chains: A, B
Length: 341 amino acids
Theoretical weight: 37.41 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00797 (Residues: 67-406; Coverage: 89%)
Gene name: REN
Sequence domains: Eukaryotic aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 66.787Å b: 93.546Å c: 117.434Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.215 0.301
Expression system: Not provided