PDBe 3d87

X-ray diffraction
2.9Å resolution

Crystal structure of Interleukin-23

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero tetramer
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-12 subunit beta Chains: B, D
Molecule details ›
Chains: B, D
Length: 306 amino acids
Theoretical weight: 34.75 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P29460 (Residues: 23-328; Coverage: 100%)
Gene names: IL12B, NKSF2
Sequence domains: Cytokine interleukin-12p40 C-terminus
Structure domains: Immunoglobulins
Interleukin-23 subunit alpha Chains: A, C
Molecule details ›
Chains: A, C
Length: 178 amino acids
Theoretical weight: 19.67 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9NPF7 (Residues: 20-189; Coverage: 100%)
Gene names: IL23A, SGRF, UNQ2498/PRO5798
Sequence domains: Interleukin 23 subunit alpha

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: C2221
Unit cell:
a: 110.098Å b: 240.587Å c: 141.781Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.269 0.268 0.323
Expression system: Trichoplusia ni