PDBe 3d18

X-ray diffraction
1.74Å resolution

Crystal structure of HLA-B*2709 complexed with a variant of the latent membrane protein 2 peptide (LMP2(L)) of epstein-barr virus

Released:
Entry authors: Beltrami A, Gabdulkhakov A, Rossmann M, Ziegler A, Uchanska-Ziegler B, Saenger W

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, B-27 alpha chain Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03989 (Residues: 25-300; Coverage: 82%)
Gene names: HLA-B, HLAB
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Latent membrane protein 2 Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.32 KDa
Source organism: Human gammaherpesvirus 4
Expression system: Not provided

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P212121
Unit cell:
a: 50.753Å b: 82.56Å c: 108.993Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.233
Expression systems:
  • Escherichia coli
  • Not provided