PDBe 3czh

X-ray diffraction
2.3Å resolution

Crystal structure of CYP2R1 in complex with vitamin D2

Source organism: Homo sapiens
Entry authors: Strushkevich NV, Tempel W, Gilep AA, Loppnau P, Arrowsmith CH, Edwards AM, Bountra C, Wilkstrom M, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
Calciol + O(2) + [reduced NADPH--hemoprotein reductase] = calcidiol + [oxidized NADPH--hemoprotein reductase] + H(2)O
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Vitamin D 25-hydroxylase Chains: A, B
Molecule details ›
Chains: A, B
Length: 481 amino acids
Theoretical weight: 55.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q6VVX0 (Residues: 32-501; Coverage: 94%)
Gene name: CYP2R1
Sequence domains: Cytochrome P450
Structure domains: Cytochrome p450

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2221
Unit cell:
a: 137.361Å b: 163.393Å c: 152.289Å
α: 90° β: 90° γ: 90°
R R work R free
0.206 0.205 0.231
Expression system: Escherichia coli