PDBe 3cu1

X-ray diffraction
2.6Å resolution

Crystal Structure of 2:2:2 FGFR2D2:FGF1:SOS complex

Released:
Source organism: Homo sapiens
Entry authors: Guo F, Dakshinamurthy R, Thallapuranam SKK, Sakon J

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fibroblast growth factor receptor 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 100 amino acids
Theoretical weight: 11.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21802 (Residues: 150-249; Coverage: 13%)
Gene names: BEK, FGFR2, KGFR, KSAM
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins
Fibroblast growth factor 1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 131 amino acids
Theoretical weight: 14.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05230 (Residues: 22-152; Coverage: 85%)
Gene names: FGF1, FGFA
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 85.929Å b: 110.375Å c: 74.699Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.18 0.277
Expression system: Escherichia coli