PDBe 3ckk

X-ray diffraction
1.55Å resolution

Crystal structure of human methyltransferase-like protein 1

Released:
Source organism: Homo sapiens
Entry authors: Dong A, Zeng H, Dobrovetsky E, Bountra C, Weigelt J, Arrowsmith CH, Edwards AM, Bochkarev A, Min J, Plotnikov AN, Wu H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA. 
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
tRNA (guanine-N(7)-)-methyltransferase Chain: A
Molecule details ›
Chain: A
Length: 235 amino acids
Theoretical weight: 27.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UBP6 (Residues: 32-265; Coverage: 85%)
Gene names: C12orf1, METTL1
Sequence domains: Putative methyltransferase
Structure domains: Vaccinia Virus protein VP39

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P65
Unit cell:
a: 90.316Å b: 90.316Å c: 54.94Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.199 0.218
Expression system: Escherichia coli