PDBe 3ceh

X-ray diffraction
2.8Å resolution

Human liver glycogen phosphorylase (tense state) in complex with the allosteric inhibitor AVE5688

Released:

Function and Biology Details

Reaction catalysed:
((1->4)-alpha-D-glucosyl)(n) + phosphate = ((1->4)-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycogen phosphorylase, liver form Chains: A, B
Molecule details ›
Chains: A, B
Length: 809 amino acids
Theoretical weight: 93.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06737 (Residues: 24-832; Coverage: 96%)
Gene name: PYGL
Sequence domains: Carbohydrate phosphorylase
Structure domains: Glycogen Phosphorylase B;

Ligands and Environments


Cofactor: Ligand PLP 2 x PLP

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P31
Unit cell:
a: 124.115Å b: 124.115Å c: 122.491Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.17 0.165 0.247
Expression system: Spodoptera frugiperda