PDBe 3cbp

X-ray diffraction
1.42Å resolution

Set7/9-ER-Sinefungin complex

Released:

Function and Biology Details

Reaction catalysed:
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone-lysine N-methyltransferase SETD7 Chain: A
Molecule details ›
Chain: A
Length: 256 amino acids
Theoretical weight: 28.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WTS6 (Residues: 111-366; Coverage: 70%)
Gene names: KIAA1717, KMT7, SET7, SET9, SETD7
Sequence domains: SET domain
Structure domains:
Estrogen receptor Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.15 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P03372 (Residues: 298-307; Coverage: 2%)
Gene names: ESR, ESR1, NR3A1

Ligands and Environments


Cofactor: Ligand SFG 1 x SFG
2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P21212
Unit cell:
a: 102.042Å b: 38.786Å c: 66.571Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.239 0.243
Expression systems:
  • Escherichia coli
  • Not provided