PDBe 3c5j

X-ray diffraction
1.8Å resolution

Crystal structure of HLA DR52c

Released:
Source organism: Homo sapiens
Primary publication:
The structure of HLA-DR52c: comparison to other HLA-DRB3 alleles.
Proc. Natl. Acad. Sci. U.S.A. 105 11893-7 (2008)
PMID: 18697946

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
hetero hexamer
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
MHC class II antigen Chain: B
Molecule details ›
Chain: B
Length: 190 amino acids
Theoretical weight: 22.12 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: B8YAC7 (Residues: 1-183; Coverage: 100%)
Gene name: HLA-DRB3
Sequence domains:
Structure domains:
Elongation factor 1-alpha 2 Chain: C
Molecule details ›
Chain: C
Length: 13 amino acids
Theoretical weight: 1.39 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q05639 (Residues: 343-355; Coverage: 3%)
Gene names: EEF1A2, EEF1AL, STN
HLA class II histocompatibility antigen, DR alpha chain Chain: A
Molecule details ›
Chain: A
Length: 181 amino acids
Theoretical weight: 21.08 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01903 (Residues: 26-206; Coverage: 79%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P4322
Unit cell:
a: 83.38Å b: 83.38Å c: 132.91Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.202 0.227
Expression system: Spodoptera frugiperda