PDBe 3bz3

X-ray diffraction
2.2Å resolution

Crystal Structure Analysis of Focal Adhesion Kinase with a Methanesulfonamide Diaminopyrimidine Inhibitor


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Focal adhesion kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.76 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: NEW Q05397 (Residues: 414-689; Coverage: 26%)
Gene names: FAK, FAK1, PTK2
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ DW
Spacegroup: P21
Unit cell:
a: 45.46Å b: 47.825Å c: 63.067Å
α: 90° β: 98.43° γ: 90°
R R work R free
0.16 0.156 0.234
Expression system: Spodoptera frugiperda