PDBe 3bxn

X-ray diffraction
1.86Å resolution

The high resolution crystal structure of HLA-B*1402 complexed with a Cathepsin A signal sequence peptide, pCatA

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
MHC class I antigen Chain: A
Molecule details ›
Chain: A
Length: 278 amino acids
Theoretical weight: 32.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q56H30 (Residues: 10-286; Coverage: 94%)
Gene name: HLA-B
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Lysosomal protective protein Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 982 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10619 (Residues: 2-10; Coverage: 0%)
Gene names: CTSA, PPGB

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P212121
Unit cell:
a: 50.791Å b: 82.144Å c: 110.734Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.169 0.219
Expression systems:
  • Escherichia coli
  • Not provided