PDBe 3btr

X-ray diffraction
2.6Å resolution

AR-NLS:Importin-alpha complex

Source organisms:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin subunit alpha-1 Chain: C
Molecule details ›
Chain: C
Length: 427 amino acids
Theoretical weight: 46.3 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
  • Canonical: P52293 (Residues: 70-496; Coverage: 81%)
Gene names: Kpna2, Rch1
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant
Androgen receptor Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P10275 (Residues: 622-636; Coverage: 2%)
Gene names: AR, DHTR, NR3C4

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P212121
Unit cell:
a: 78.274Å b: 89.372Å c: 98.104Å
α: 90° β: 90° γ: 90°
R R work R free
0.189 0.186 0.229
Expression system: Escherichia coli