PDBe 3bta

X-ray diffraction
3.2Å resolution

CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN SEROTYPE A

Released:
Source organism: Clostridium botulinum

Function and Biology Details

Reaction catalysed:
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevin (also known as neuronal vesicle-associated membrane protein, VAMP), synaptosome-associated protein of 25 kDa (SNAP25) or syntaxin. No detected action on small molecule substrates.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Botulinum neurotoxin type A Chain: A
Molecule details ›
Chain: A
Length: 1295 amino acids
Theoretical weight: 149.48 KDa
Source organism: Clostridium botulinum
UniProt:
  • Canonical: P0DPI0 (Residues: 2-1296; Coverage: 100%)
Gene names: atx, bonT, botA
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P3121
Unit cell:
a: 170.12Å b: 170.12Å c: 161Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.22 0.22 0.28