› 3bt0

X-ray diffraction
1.59Å resolution

Crystal structure of transthyretin variant V20S

Released:
DOI: 10.2210/pdb3bt0/pdb
PDB entry 3bt0 coloured by chain, front view.
PDB entry 3bt0 coloured by chain, side view.
PDB entry 3bt0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and mutational analyses of protein-protein interactions between transthyretin and retinol-binding protein.
Zanotti G, Folli C, Cendron L, Alfieri B, Nishida SK, Gliubich F, Pasquato N, Negro A, Berni R
FEBS J 275 5841-54 (2008)
PMID: 19021760

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21212
Unit cell:
a: 41.999Å b: 83.812Å c: 65.58Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.209 0.229
Expression system: Escherichia coli

Quick links

Citations

3 review citations

A Narrative Review of the Role of Transthyretin in Health and Disease.
Liz et al. (2020)
2 more