PDBe 3bpo

X-ray diffraction
3Å resolution

Crystal structure of the IL13-IL4R-IL13Ra ternary complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interleukin-13 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 14.14 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35225 (Residues: 34-73, 74-146; Coverage: 100%)
Gene names: IL13, NC30
Structure domains: Growth Hormone; Chain: A;
Soluble interleukin-4 receptor subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 205 amino acids
Theoretical weight: 23.47 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24394 (Residues: 27-227; Coverage: 25%)
Gene names: 582J2.1, IL4R, IL4RA
Sequence domains: Interleukin-4 receptor alpha chain, N-terminal
Structure domains: Immunoglobulins
Interleukin-13 receptor subunit alpha-1 Chain: C
Molecule details ›
Chain: C
Length: 314 amino acids
Theoretical weight: 36.36 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P78552 (Residues: 29-342; Coverage: 77%)
Gene names: IL13R, IL13RA, IL13RA1
Sequence domains: Interleukin-6 receptor alpha chain, binding
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: C2
Unit cell:
a: 211.51Å b: 58.169Å c: 64.236Å
α: 90° β: 100.51° γ: 90°
R-values:
R R work R free
0.256 0.253 0.312
Expression system: Spodoptera frugiperda