PDBe 3bp7

X-ray diffraction
1.8Å resolution

The high resolution crystal structure of HLA-B*2709 in complex with a Cathepsin A signal sequence peptide, pCatA

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, B-27 alpha chain Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P03989 (Residues: 25-300; Coverage: 82%)
Gene names: HLA-B, HLAB
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Lysosomal protective protein Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 982 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10619 (Residues: 2-10; Coverage: 0%)
Gene names: CTSA, PPGB

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P212121
Unit cell:
a: 51.195Å b: 83.002Å c: 110.779Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 0.167 0.204
Expression systems:
  • Escherichia coli BL21
  • Escherichia coli
  • Not provided