PDBe 3bo8

X-ray diffraction
1.8Å resolution

The High Resolution Crystal Structure of HLA-A1 Complexed with the MAGE-A1 Peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Melanoma-associated antigen 1 Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 977 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P43355 (Residues: 161-169; Coverage: 3%)
Gene names: MAGE1, MAGE1A, MAGEA1
HLA class I histocompatibility antigen, A-1 alpha chain Chain: A
Molecule details ›
Chain: A
Length: 274 amino acids
Theoretical weight: 31.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P30443 (Residues: 25-298; Coverage: 80%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P212121
Unit cell:
a: 51.176Å b: 74.06Å c: 125.94Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.195 0.225
Expression systems:
  • Escherichia coli
  • Not provided
  • Escherichia coli BL21(DE3)