PDBe 3bkj

X-ray diffraction
1.59Å resolution

Crystal structure of Fab wo2 bound to the n terminal domain of amyloid beta peptide (1-16)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Amyloid-beta protein 40 Chain: A
Molecule details ›
Chain: A
Length: 16 amino acids
Theoretical weight: 1.96 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 672-687; Coverage: 2%)
Gene names: A4, AD1, APP
Ig heavy chain Mem5 Chain: H
Molecule details ›
Chain: H
Length: 224 amino acids
Theoretical weight: 24.43 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P84751 (Residues: 2-29, 30-102, 103-107, 108-220; Coverage: 91%)
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
If kappa light chain Chain: L
Molecule details ›
Chain: L
Length: 252 amino acids
Theoretical weight: 27.82 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: A2NHM3 (Residues: 1-219; Coverage: 100%)
Gene names: Igk-C, Igkc
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P212121
Unit cell:
a: 51.743Å b: 66.632Å c: 115.16Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.188 0.231
Expression system: Not provided