PDBe 3bce

X-ray diffraction
2.5Å resolution

Crystal structure of the ErbB4 kinase


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
ERBB4 intracellular domain Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 328 amino acids
Theoretical weight: 37.49 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: NEW Q15303 (Residues: 702-1029; Coverage: 26%)
Gene names: ERBB4, HER4
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P32
Unit cell:
a: 86.723Å b: 86.723Å c: 120.008Å
α: 90° β: 90° γ: 120°
R R work R free
0.198 0.195 0.251
Expression system: Spodoptera frugiperda