PDBe 3bbt

X-ray diffraction
2.8Å resolution

crystal structure of the ErbB4 kinase in complex with lapatinib


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
ERBB4 intracellular domain Chains: B, D
Molecule details ›
Chains: B, D
Length: 328 amino acids
Theoretical weight: 37.49 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: NEW Q15303 (Residues: 702-1029; Coverage: 26%)
Gene names: ERBB4, HER4
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P61
Unit cell:
a: 102.682Å b: 102.682Å c: 185.124Å
α: 90° β: 90° γ: 120°
R R work R free
0.253 0.251 0.289
Expression system: Spodoptera frugiperda