PDBe 3b96

X-ray diffraction
1.91Å resolution

Structural Basis for Substrate Fatty-Acyl Chain Specificity: Crystal Structure of Human Very-Long-Chain Acyl-CoA Dehydrogenase

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 587 amino acids
Theoretical weight: 63.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49748 (Residues: 69-655; Coverage: 90%)
Gene names: ACADVL, VLCAD
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 1 x FAD
1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: null, APS BEAMLINE 19-ID, APS BEAMLINE 5ID-B
Spacegroup: C2221
Unit cell:
a: 74.616Å b: 107.879Å c: 149.776Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.162 0.159 0.216
Expression system: Escherichia coli BL21(DE3)