PDBe 3b71

X-ray diffraction
2.82Å resolution

CD4 endocytosis motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase

Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Focal adhesion kinase 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 162 amino acids
Theoretical weight: 17.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: NEW Q05397 (Residues: 891-1052; Coverage: 15%)
Gene names: FAK, FAK1, PTK2
Sequence domains: Focal adhesion targeting region
Structure domains:
T-cell surface glycoprotein CD4 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 23 amino acids
Theoretical weight: 2.78 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: NEW P01730 (Residues: 428-450; Coverage: 5%)
Gene name: CD4

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: C2221
Unit cell:
a: 88.071Å b: 220.472Å c: 97.546Å
α: 90° β: 90° γ: 90°
R R work R free
0.242 0.241 0.307
Expression systems:
  • Escherichia coli BL21
  • Not provided