PDBe 3b56

X-ray diffraction
1.55Å resolution

Crystal structure of transthyretin in complex with 3,5-diiodosalicylic acid

Released:
Source organism: Homo sapiens
Primary publication:
Iodination of salicylic acid improves its binding to transthyretin.
Biochim. Biophys. Acta 1784 512-7 (2008)
PMID: 18155178

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P21212
Unit cell:
a: 42.539Å b: 85.757Å c: 64.346Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.189 0.214
Expression system: Escherichia coli BL21