PDBe 3b2v

X-ray diffraction
3.3Å resolution

Crystal structure of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
IGH@ protein Chain: H
Molecule details ›
Chain: H
Length: 223 amino acids
Theoretical weight: 23.6 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: Q6GMX6 (Residues: 20-50, 51-116, 117-237; Coverage: 49%)
Gene name: IGH@
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
IMC-11F8 FAB Light chain Chain: L
Molecule details ›
Chain: L
Length: 213 amino acids
Theoretical weight: 23.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Structure domains: Immunoglobulins
Epidermal growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 624 amino acids
Theoretical weight: 69.2 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: P00533 (Residues: 25-642; Coverage: 52%)
  • Best match: P00533-4 (Residues: 25-627)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: C2221
Unit cell:
a: 68.743Å b: 266.242Å c: 156.381Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.286 0.282 0.367
Expression systems:
  • Mus musculus
  • Spodoptera frugiperda