PDBe 3b13

X-ray diffraction
3.01Å resolution

Crystal structure of the DHR-2 domain of DOCK2 in complex with Rac1 (T17N mutant)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Dedicator of cytokinesis protein 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 431 amino acids
Theoretical weight: 51.11 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q92608 (Residues: 1196-1622; Coverage: 23%)
Gene names: DOCK2, KIAA0209
Structure domains:
Ras-related C3 botulinum toxin substrate 1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 184 amino acids
Theoretical weight: 20.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63000 (Residues: 1-177; Coverage: 92%)
Gene names: MIG5, RAC1, TC25
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P65
Unit cell:
a: 168.651Å b: 168.651Å c: 129.718Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.185 0.183 0.234
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli