PDBe 3am8

X-ray diffraction
2.8Å resolution

Crystal Structure of a Human Major Histocompatibilty complex

Released:
Entry authors: Chacko J, Clements C, Rossjohn J

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Soluble HLA class I histocompatibility antigen, alpha chain E Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 31.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13747 (Residues: 22-297; Coverage: 82%)
Gene names: HLA-6.2, HLA-E, HLAE
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: C, D
Molecule details ›
Chains: C, D
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Glycoprotein Chains: E, F
Molecule details ›
Chains: E, F
Length: 9 amino acids
Theoretical weight: 1 KDa
Source organism: Human betaherpesvirus 5
Expression system: Not provided
UniProt:
  • Canonical: Q0QI92 (Residues: 15-23; Coverage: 4%)
Gene name: UL40

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 58.628Å b: 99.237Å c: 76.59Å
α: 90° β: 92.72° γ: 90°
R-values:
R R work R free
0.198 0.185 0.251
Expression systems:
  • Escherichia coli
  • Not provided