PDBe 3a98

X-ray diffraction
2.1Å resolution

Crystal structure of the complex of the interacting regions of DOCK2 and ELMO1

Released:
Source organism: Homo sapiens
Entry authors: Hanawa-Suetsugu K, Kukimoto-Niino M, Sekine S, Ito T, Mishima-Tsumagari C, Terada T, Shirouzu M, Fukui Y, Yokoyama S

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Dedicator of cytokinesis protein 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 184 amino acids
Theoretical weight: 21.4 KDa
Source organism: Homo sapiens
Expression system: Cell free protein synthesis
UniProt:
  • Canonical: Q92608 (Residues: 1-177; Coverage: 10%)
Gene names: DOCK2, KIAA0209
Structure domains:
Engulfment and cell motility protein 1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 203 amino acids
Theoretical weight: 23.41 KDa
Source organism: Homo sapiens
Expression system: Cell free protein synthesis
UniProt:
  • Canonical: Q92556 (Residues: 532-727; Coverage: 27%)
Gene names: ELMO1, KIAA0281
Sequence domains: Pleckstrin homology domain
Structure domains:

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P212121
Unit cell:
a: 63.837Å b: 104.028Å c: 124.731Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.226 0.268
Expression system: Cell free protein synthesis