PDBe 3a7j

X-ray diffraction
1.5Å resolution

Human MST3 kinase in complex with MnADP

Source organism: Homo sapiens
Primary publication:
Structures of human MST3 kinase in complex with adenine, ADP and Mn2+.
Acta Crystallogr. D Biol. Crystallogr. 66 145-54 (2010)
PMID: 20124694

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Serine/threonine-protein kinase 24 36 kDa subunit Chain: A
Molecule details ›
Chain: A
Length: 303 amino acids
Theoretical weight: 34.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9Y6E0 (Residues: 10-315; Coverage: 68%)
  • Best match: Q9Y6E0-2 (Residues: 1-303)
Gene names: MST3, STK24, STK3
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P21
Unit cell:
a: 47.816Å b: 53.527Å c: 60.634Å
α: 90° β: 109.95° γ: 90°
R R work R free
0.191 0.186 0.21
Expression system: Escherichia coli