PDBe 3a7h

X-ray diffraction
1.96Å resolution

Human MST3 kinase in complex with ATP

Released:
Source organism: Homo sapiens
Primary publication:
Structures of human MST3 kinase in complex with adenine, ADP and Mn2+.
Acta Crystallogr. D Biol. Crystallogr. 66 145-54 (2010)
PMID: 20124694

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 24 36 kDa subunit Chains: A, B
Molecule details ›
Chains: A, B
Length: 303 amino acids
Theoretical weight: 34.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y6E0 (Residues: 10-315; Coverage: 68%)
  • Best match: Q9Y6E0-2 (Residues: 1-303)
Gene names: MST3, STK24, STK3
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL12B2
Spacegroup: P21
Unit cell:
a: 55.678Å b: 95.194Å c: 61.482Å
α: 90° β: 93.45° γ: 90°
R-values:
R R work R free
0.21 0.204 0.252
Expression system: Escherichia coli