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Crystal structure of the human RXR alpha ligand binding domain bound to a synthetic agonist compound and a coactivator peptide

X-ray diffraction
3Å resolution
PDB entry 2zxz coloured by chain, front view.
PDB entry 2zxz coloured by chain, side view.
PDB entry 2zxz coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: RXRalpha-NCOA2 activated retinoic acid receptor complex
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Multimeric state: hetero tetramer
Accessible surface area: 19604.32 Å2
Buried surface area: 4533.31 Å2
Dissociation area: 1,134.66 Å2
Dissociation energy (ΔGdiss): -6.99 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-148727
Complex Portal ID: CPX-513

Macromolecules

Retinoic acid receptor RXR-alpha
Chain: A
Length: 240 amino acids
Theoretical weight: 26.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19793 (Residues: 223-462; Coverage: 52%)
Gene names: NR2B1, RXRA
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
Retinoic acid receptor RXR-alpha in PDB entry 2zxz, assembly 1, front view.
Retinoic acid receptor RXR-alpha in PDB entry 2zxz, assembly 1, side view.
Retinoic acid receptor RXR-alpha in PDB entry 2zxz, assembly 1, top view.
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Nuclear receptor coactivator 2
Chain: B
Length: 13 amino acids
Theoretical weight: 1.58 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 686-698; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2
Nuclear receptor coactivator 2 in PDB entry 2zxz, assembly 1, front view.
Nuclear receptor coactivator 2 in PDB entry 2zxz, assembly 1, side view.
Nuclear receptor coactivator 2 in PDB entry 2zxz, assembly 1, top view.
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