› 2zv8

X-ray diffraction
2.7Å resolution

Lyn Tyrosine Kinase Domain-AMP-PNP complex

Released:
DOI: 10.2210/pdb2zv8/pdb
PDB entry 2zv8 coloured by chain, front view.
PDB entry 2zv8 coloured by chain, side view.
PDB entry 2zv8 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound state.
Williams NK, Lucet IS, Klinken SP, Ingley E, Rossjohn J
J Biol Chem 284 284-291 (2009)
PMID: 18984583

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150611 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Lyn Chain: A
Molecule details ›
Chain: A
Length: 279 amino acids
Theoretical weight: 31.81 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P25911 (Residues: 239-512; Coverage: 54%)
Gene name: Lyn
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ANP 1 x ANP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: R3
Unit cell:
a: 127.239Å b: 127.239Å c: 54.875Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.199 0.245
Expression system: Spodoptera frugiperda

Quick links

Citations

6 review citations

Polyproline-II helix in proteins: structure and function.
Adzhubei et al. (2013)
5 more

2 mentions without citation

Mechanisms of drug resistance in kinases.
Barouch-Bentov et al. (2011)
1 more