PDBe 2zv2

X-ray diffraction
2.4Å resolution

Crystal structure of human calcium/calmodulin-dependent protein kinase kinase 2, beta, CaMKK2 kinase domain in complex with STO-609


Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Calcium/calmodulin-dependent protein kinase kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 33.61 KDa
Source organism: Homo sapiens
Expression system: Cell Free Protein Synthesis
  • Canonical: Q96RR4 (Residues: 158-448; Coverage: 50%)
Gene names: CAMKK2, CAMKKB, KIAA0787
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P212121
Unit cell:
a: 67.368Å b: 77.153Å c: 84.332Å
α: 90° β: 90° γ: 90°
R R work R free
0.203 0.203 0.252
Expression system: Cell Free Protein Synthesis