EC 2.3.2.27: RING-type E3 ubiquitin transferase
Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
- RING E3 ligase
- Ubiquitin transferase RING E3
GO terms
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Protein family (Pfam)![The deposited structure of PDB entry 2zo1 contains 1 copy of Pfam domain PF02182 (SAD/SRA domain) in E3 ubiquitin-protein ligase UHRF1. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/2zo1_3_B_Pfam_PF02182_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2zo1</span> contains 1 copy of Pfam domain <span class='highlight'>PF02182 (SAD/SRA domain)</span> in <span class='highlight'>E3 ubiquitin-protein ligase UHRF1</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>.")
InterPro annotations
CATH domain![The deposited structure of PDB entry 2zo1 contains 1 copy of CATH domain 2.30.280.10 (PUA domain-like) in E3 ubiquitin-protein ligase UHRF1. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/2zo1_3_B_CATH_2.30.280.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2zo1</span> contains 1 copy of CATH domain <span class='highlight'>2.30.280.10 (PUA domain-like)</span> in <span class='highlight'>E3 ubiquitin-protein ligase UHRF1</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>.")
SCOP annotation![The deposited structure of PDB entry 2zo1 contains 1 copy of SCOP domain 159368 (SRA domain-like) in E3 ubiquitin-protein ligase UHRF1. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/2zo1_3_B_SCOP_159368_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2zo1</span> contains 1 copy of SCOP domain <span class='highlight'>159368 (SRA domain-like)</span> in <span class='highlight'>E3 ubiquitin-protein ligase UHRF1</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>.")