PDBe 2znp

X-ray diffraction
3Å resolution

Human PPAR delta ligand binding domain in complex with a synthetic agonist TIPP204


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Peroxisome proliferator-activated receptor delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 31.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: Q03181 (Residues: 170-441; Coverage: 62%)
Gene names: NR1C2, PPARB, PPARD
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL38B1
Spacegroup: P21
Unit cell:
a: 39.492Å b: 93.149Å c: 96.37Å
α: 90° β: 97.48° γ: 90°
R R work R free
0.23 0.23 0.288
Expression system: Escherichia coli BL21