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Complex Structure of Insulin-like Growth Factor Receptor and Isoquinolinedione Inhibitor

X-ray diffraction
2.5Å resolution
PDB entry 2zm3 coloured by chain, front view.
PDB entry 2zm3 coloured by chain, side view.
PDB entry 2zm3 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo octamer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Insulin-like growth factor 1 receptor alpha chain
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Multimeric state: monomeric
Accessible surface area: 15270.18 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139909
Assembly 2
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Assembly Name: Insulin-like growth factor 1 receptor alpha chain
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Multimeric state: monomeric
Accessible surface area: 15055.56 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139909
Assembly 3
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Assembly Name: Insulin-like growth factor 1 receptor alpha chain
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Multimeric state: monomeric
Accessible surface area: 15109.4 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139909
Assembly 4
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Assembly Name: Insulin-like growth factor 1 receptor alpha chain
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Multimeric state: monomeric
Accessible surface area: 15035.0 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139909
Assembly 5
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Assembly Name: Insulin-like growth factor 1 receptor alpha chain
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Multimeric state: homo octamer
Accessible surface area: 102413.69 Å2
Buried surface area: 18538.4 Å2
Dissociation area: 9,269.2 Å2
Dissociation energy (ΔGdiss): 41.89 kcal/mol
Dissociation entropy (TΔSdiss): 100.8 kcal/mol
Symmetry number: 8
PDBe Complex ID: PDB-CPX-139914

Macromolecules

Insulin-like growth factor 1 receptor beta chain
Chains: A, B, C, D
Length: 308 amino acids
Theoretical weight: 35.34 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P08069 (Residues: 981-1286; Coverage: 23%)
Gene name: IGF1R
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Insulin-like growth factor 1 receptor beta chain in PDB entry 2zm3, assembly 1, front view.
Insulin-like growth factor 1 receptor beta chain in PDB entry 2zm3, assembly 1, side view.
Insulin-like growth factor 1 receptor beta chain in PDB entry 2zm3, assembly 1, top view.
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