PDBe 2zm3

X-ray diffraction
2.5Å resolution

Complex Structure of Insulin-like Growth Factor Receptor and Isoquinolinedione Inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo octamer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor 1 receptor beta chain Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 308 amino acids
Theoretical weight: 35.34 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P08069 (Residues: 981-1286; Coverage: 23%)
Gene name: IGF1R
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 137.725Å b: 135.962Å c: 86.38Å
α: 90° β: 114.27° γ: 90°
R-values:
R R work R free
0.204 0.201 0.257
Expression system: Not provided