PDBe 2zky

X-ray diffraction
2.4Å resolution

Crystal structure of human Cu-Zn superoxide dismutase mutant G93A

Released:
Source organism: Homo sapiens
Entry authors: Yoshikawa S, Kukimoto-Niino M, Ito K, Shirouzu M, Urushitani M, Takahashi R, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase [Cu-Zn] Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 159 amino acids
Theoretical weight: 16.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00441 (Residues: 1-154; Coverage: 100%)
Gene name: SOD1
Sequence domains: Copper/zinc superoxide dismutase (SODC)
Structure domains: Superoxide dismutase, copper/zinc binding domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: C2221
Unit cell:
a: 165.238Å b: 204.509Å c: 144.819Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.189 0.235
Expression system: Escherichia coli