EC 2.7.11.2: [Pyruvate dehydrogenase (acetyl-transferring)] kinase
Reaction catalysed:
ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate
Systematic name:
ATP:[pyruvate dehydrogenase (acetyl-transferring)] phosphotransferase
Alternative Name(s):
- PDH kinase
- PDHK
- PDK
- PDK1
- PDK2
- PDK3
- PDK4
- Pyruvate dehydrogenase kinase
- Pyruvate dehydrogenase kinase (phosphorylating)
- Pyruvate dehydrogenase kinase activator protein
- STK1
GO terms
Biochemical function:
Biological process:
- negative regulation of anoikis
- reactive oxygen species metabolic process
- cellular response to fatty acid
- regulation of fatty acid oxidation
- regulation of bone resorption
- response to starvation
- glucose homeostasis
- regulation of fatty acid biosynthetic process
- regulation of glucose metabolic process
- regulation of cellular ketone metabolic process
- regulation of acetyl-CoA biosynthetic process from pyruvate
- cellular response to starvation
- insulin receptor signaling pathway
- regulation of pH
Cellular component:
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 2zkj contains 2 copies of Pfam domain PF02518 (Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) in [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/2zkj_1_B_Pfam_PF02518_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2zkj</span> contains 2 copies of Pfam domain <span class='highlight'>PF02518 (Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase)</span> in <span class='highlight'>[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>B</span>.")
![The deposited structure of PDB entry 2zkj contains 2 copies of Pfam domain PF10436 (Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase) in [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/2zkj_1_B_Pfam_PF10436_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2zkj</span> contains 2 copies of Pfam domain <span class='highlight'>PF10436 (Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase)</span> in <span class='highlight'>[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>B</span>.")
InterPro annotations
IPR036784
Domain description:
Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily
Occurring in:
Occurring in:
IPR018955
Domain description:
Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
Occurring in:
Occurring in:
Structure domains
CATH domains
3.30.565.10
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Heat Shock Protein 90
Homology:
Histidine kinase-like ATPase, C-terminal domain
Occurring in:
![The deposited structure of PDB entry 2zkj contains 2 copies of CATH domain 3.30.565.10 (Heat Shock Protein 90) in [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/2zkj_1_B_CATH_3.30.565.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2zkj</span> contains 2 copies of CATH domain <span class='highlight'>3.30.565.10 (Heat Shock Protein 90)</span> in <span class='highlight'>[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>B</span>.")
![The deposited structure of PDB entry 2zkj contains 2 copies of CATH domain 1.20.140.20 (Butyryl-CoA Dehydrogenase, subunit A; domain 3) in [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/2zkj_1_B_CATH_1.20.140.20_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2zkj</span> contains 2 copies of CATH domain <span class='highlight'>1.20.140.20 (Butyryl-CoA Dehydrogenase, subunit A; domain 3)</span> in <span class='highlight'>[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>B</span>.")