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Crystal structure of human prostate specific antigen complexed with an activating antibody

X-ray diffraction
3.25Å resolution
PDB entry 2zcl coloured by chain, front view.
PDB entry 2zcl coloured by chain, side view.
PDB entry 2zcl coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Prostate-specific antigen and IG-light kappa chain and IG-heavy chain
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Multimeric state: hetero trimer
Accessible surface area: 31042.71 Å2
Buried surface area: 5706.23 Å2
Dissociation area: 832.96 Å2
Dissociation energy (ΔGdiss): -1.74 kcal/mol
Dissociation entropy (TΔSdiss): 13.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-233927

Macromolecules

Prostate-specific antigen
Chain: P
Length: 237 amino acids
Theoretical weight: 26.12 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P07288 (Residues: 25-261; Coverage: 97%)
Gene names: APS, KLK3
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
Prostate-specific antigen in PDB entry 2zcl, assembly 1, front view.
Prostate-specific antigen in PDB entry 2zcl, assembly 1, side view.
Prostate-specific antigen in PDB entry 2zcl, assembly 1, top view.
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monoclonal antibody 8G8F5 Fab
Chain: L
Length: 218 amino acids
Theoretical weight: 23.79 KDa
Source organism: Mus musculus
InterPro:
CATH: Immunoglobulins
monoclonal antibody 8G8F5 Fab in PDB entry 2zcl, assembly 1, front view.
monoclonal antibody 8G8F5 Fab in PDB entry 2zcl, assembly 1, side view.
monoclonal antibody 8G8F5 Fab in PDB entry 2zcl, assembly 1, top view.
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monoclonal antibody 8G8F5 Fab
Chain: H
Length: 230 amino acids
Theoretical weight: 24.48 KDa
Source organism: Mus musculus
InterPro:
CATH: Immunoglobulins
monoclonal antibody 8G8F5 Fab in PDB entry 2zcl, assembly 1, front view.
monoclonal antibody 8G8F5 Fab in PDB entry 2zcl, assembly 1, side view.
monoclonal antibody 8G8F5 Fab in PDB entry 2zcl, assembly 1, top view.
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