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Structure of a GTP-dependent bacterial PEP-carboxykinase from Corynebacterium glutamicum

Source organism: Corynebacterium glutamicum
Biochemical function: metal ion binding
Biological process: cellular response to dexamethasone stimulus
Cellular component: cytosol

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EC 4.1.1.32: Phosphoenolpyruvate carboxykinase (GTP)

Reaction catalysed:
GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO(2)
Systematic name:
GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)
Alternative Name(s):
  • GTP:oxaloacetate carboxy-lyase (transphosphorylating)
  • PEP carboxykinase
  • PEP carboxylase
  • PEPCK
  • Phosphoenolpyruvate carboxykinase
  • Phosphoenolpyruvate carboxylase
  • Phosphoenolpyruvic carboxykinase
  • Phosphoenolpyruvic carboxykinase (GTP)
  • Phosphoenolpyruvic carboxylase (GTP)
  • Phosphopyruvate (guanosine triphosphate) carboxykinase
  • Phosphopyruvate carboxylase
  • Phosphopyruvate carboxylase (GTP)

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00821
Domain description: Phosphoenolpyruvate carboxykinase C-terminal P-loop domain
Occurring in:
  1. Phosphoenolpyruvate carboxykinase [GTP]
The deposited structure of PDB entry 2zci contains 4 copies of Pfam domain PF00821 (Phosphoenolpyruvate carboxykinase C-terminal P-loop domain) in Phosphoenolpyruvate carboxykinase [GTP]. Showing 1 copy in chain A.

PF17297
Domain description: Phosphoenolpyruvate carboxykinase N-terminal domain
Occurring in:
  1. Phosphoenolpyruvate carboxykinase [GTP]
The deposited structure of PDB entry 2zci contains 4 copies of Pfam domain PF17297 (Phosphoenolpyruvate carboxykinase N-terminal domain) in Phosphoenolpyruvate carboxykinase [GTP]. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR008209
Domain description: Phosphoenolpyruvate carboxykinase, GTP-utilising
Occurring in:
  1. Phosphoenolpyruvate carboxykinase [GTP]
IPR008210
Domain description: Phosphoenolpyruvate carboxykinase, N-terminal
Occurring in:
  1. Phosphoenolpyruvate carboxykinase [GTP]
IPR018091
Domain description: Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site
Occurring in:
  1. Phosphoenolpyruvate carboxykinase [GTP]
IPR013035
Domain description: Phosphoenolpyruvate carboxykinase, C-terminal
Occurring in:
  1. Phosphoenolpyruvate carboxykinase [GTP]
IPR035077
Domain description: Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain
Occurring in:
  1. Phosphoenolpyruvate carboxykinase [GTP]
IPR035078
Domain description: Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal
Occurring in:
  1. Phosphoenolpyruvate carboxykinase [GTP]

Structure domains

CATH CATH domains
3.90.228.20
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Phosphoenolpyruvate Carboxykinase; domain 3
Homology: Phosphoenolpyruvate Carboxykinase; domain 3
Occurring in:
  1. Phosphoenolpyruvate carboxykinase [GTP]
The deposited structure of PDB entry 2zci contains 4 copies of CATH domain 3.90.228.20 (Phosphoenolpyruvate Carboxykinase; domain 3) in Phosphoenolpyruvate carboxykinase [GTP]. Showing 1 copy in chain A.
2.170.8.10
Class: Mainly Beta
Architecture: Beta Complex
Topology: Phosphoenolpyruvate Carboxykinase; domain 2
Homology: Phosphoenolpyruvate Carboxykinase, domain 2
Occurring in:
  1. Phosphoenolpyruvate carboxykinase [GTP]
The deposited structure of PDB entry 2zci contains 4 copies of CATH domain 2.170.8.10 (Phosphoenolpyruvate Carboxykinase; domain 2) in Phosphoenolpyruvate carboxykinase [GTP]. Showing 1 copy in chain A.
3.40.449.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Phosphoenolpyruvate Carboxykinase; domain 1
Homology: Phosphoenolpyruvate Carboxykinase, domain 1
Occurring in:
  1. Phosphoenolpyruvate carboxykinase [GTP]
The deposited structure of PDB entry 2zci contains 4 copies of CATH domain 3.40.449.10 (Phosphoenolpyruvate Carboxykinase; domain 1) in Phosphoenolpyruvate carboxykinase [GTP]. Showing 1 copy in chain A.

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