Function and Biology Details
Reaction catalysed:
ATP-dependent breakage, passage and rejoining of double-stranded DNA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Spo11/DNA topoisomerase VI subunit A
- DNA topoisomerase VI, subunit A
- DNA topoisomerase VI, subunit B
- DNA topoisomerase VI, subunit B, transducer
- Histidine kinase/HSP90-like ATPase superfamily
- Ribosomal protein uS5 domain 2-type superfamily
- Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
- Small ribosomal subunit protein uS13-like, H2TH
5 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Type 2 DNA topoisomerase 6 (preferred)
PDBe Complex ID:
PDB-CPX-126469 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Type 2 DNA topoisomerase 6 subunit A
Molecule details ›
Chains: A, C, E, G
Length: 389 amino acids
Theoretical weight: 45.12 KDa
Source organism: Saccharolobus shibatae
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 389 amino acids
Theoretical weight: 45.12 KDa
Source organism: Saccharolobus shibatae
Expression system: Escherichia coli
UniProt:
- Canonical:
O05208 (Residues: 1-389; Coverage: 100%)
Sequence domains:
- Type IIB DNA topoisomerase
- All-beta domain in DNA topoisomerase VI alpha subunit
- Topoisomerase 6 subunit A/Spo11, Toprim domain
Type 2 DNA topoisomerase 6 subunit B
Molecule details ›
Chains: B, D, F, H
Length: 530 amino acids
Theoretical weight: 60.61 KDa
Source organism: Saccharolobus shibatae
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains:
Length: 530 amino acids
Theoretical weight: 60.61 KDa
Source organism: Saccharolobus shibatae
Expression system: Escherichia coli
UniProt:
- Canonical: O05207 (Residues: 1-530; Coverage: 100%)
Sequence domains:
Structure domains:
