PDBe 2zas

X-ray diffraction
2Å resolution

Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with 4-alpha-cumylphenol, a bisphenol A derivative

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen-related receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 244 amino acids
Theoretical weight: 27.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P62508 (Residues: 222-458; Coverage: 52%)
Gene names: ERR3, ERRG2, ESRRG, KIAA0832, NR3B3
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P41212
Unit cell:
a: 64.018Å b: 64.018Å c: 136.197Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.211 0.237
Expression system: Escherichia coli BL21