PDBe 2z8c

X-ray diffraction
3.25Å resolution

Phosphorylated insulin receptor tyrosine kinase in complex with (4-{[5-carbamoyl-4-(3-methylanilino)pyrimidin-2-yl]amino}phenyl)acetic acid

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin receptor subunit beta Chain: A
Molecule details ›
Chain: A
Length: 303 amino acids
Theoretical weight: 34.69 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06213 (Residues: 1008-1310; Coverage: 22%)
Gene name: INSR
Sequence domains: Protein tyrosine kinase
Structure domains:
Insulin receptor substrate 1 Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 760 Da
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35568 (Residues: 731-736; Coverage: 1%)
Gene name: IRS1

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6B
Spacegroup: P3221
Unit cell:
a: 71.54Å b: 71.54Å c: 133.85Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.217 0.292
Expression system: Spodoptera frugiperda