PDBe 2z7s

X-ray diffraction
2.1Å resolution

Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Purvalnol A


Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Ribosomal protein S6 kinase alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 321 amino acids
Theoretical weight: 36.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q15418 (Residues: 33-353; Coverage: 44%)
Gene names: MAPKAPK1A, RPS6KA1, RSK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 51.641Å b: 52.996Å c: 119.304Å
α: 90° β: 90° γ: 90°
R R work R free
0.279 0.253 not available
Expression system: Spodoptera frugiperda