PDBe 2z7q

X-ray diffraction
2Å resolution

Crystal structure of the N-terminal kinase domain of human RSK-1 bound to AMP-PCP

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosomal protein S6 kinase alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 321 amino acids
Theoretical weight: 36.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q15418 (Residues: 33-353; Coverage: 44%)
Gene names: MAPKAPK1A, RPS6KA1, RSK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 52.194Å b: 53.685Å c: 119.874Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.264 0.264 0.283
Expression system: Spodoptera frugiperda