PDBe 2z7l

X-ray diffraction
2.41Å resolution

Unphosphorylated Mitogen Activated Protein Kinase ERK2 in Complex with (4-{[5-Carbamoyl-4-(3-Methylanilino)Pyrimidin 2-Yl]Amino}Phenyl)Acetic Acid


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Mitogen-activated protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 366 amino acids
Theoretical weight: 42.36 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
  • Canonical: P63086 (Residues: 1-358; Coverage: 100%)
Gene names: Erk2, Mapk, Mapk1, Prkm1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 48.873Å b: 69.962Å c: 60.775Å
α: 90° β: 109.58° γ: 90°
R R work R free
0.223 0.223 0.276
Expression system: Escherichia coli