PDBe 2z60

X-ray diffraction
1.95Å resolution

Crystal Structure of the T315I Mutant of Abl kinase bound with PPY-A

Source organism: Mus musculus
Primary publication:
Crystal structure of the T315I mutant of AbI kinase.
Chem Biol Drug Des 70 171-81 (2007)
PMID: 17718712

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein kinase ABL1 Chain: A
Molecule details ›
Chain: A
Length: 288 amino acids
Theoretical weight: 33.25 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P00520 (Residues: 229-515; Coverage: 26%)
Gene names: Abl, Abl1
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P21
Unit cell:
a: 43.035Å b: 59.28Å c: 66.52Å
α: 90° β: 94.88° γ: 90°
R R work R free
0.206 0.206 0.245
Expression system: Escherichia coli BL21(DE3)