PDBe 2z4j

X-ray diffraction
2.6Å resolution

Crystal structure of AR LBD with SHP peptide NR Box 2

Released:
Source organism: Homo sapiens
Primary publication:
Interaction between the androgen receptor and a segment of its corepressor SHP.
Acta Crystallogr. D Biol. Crystallogr. 63 1198-200 (2007)
PMID: 18007036

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Androgen receptor Chain: A
Molecule details ›
Chain: A
Length: 248 amino acids
Theoretical weight: 28.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10275 (Residues: 672-919; Coverage: 27%)
Gene names: AR, DHTR, NR3C4
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor subfamily 0 group B member 2 Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.16 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15466 (Residues: 115-124; Coverage: 4%)
Gene names: NR0B2, SHP

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P212121
Unit cell:
a: 55.979Å b: 66.542Å c: 71.842Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.207 0.234
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided